Endocrinology and Metabolism

Editorial

Diabetes, Obesity and Metabolism
All That Glitters Is Not Gold: The Same Sleep Time, but Different Diabetogenic Outcomes: Bohye Kim, Obin Kwon; Endocrinol Metab. 2023;38(1):78-80. Published online February 27, 2023; DOI: https://doi.org/10.3803/EnM.2023.107

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Review Articles

Diabetes, Obesity and Metabolism
Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones: Bo Hye Kim, Yena Joo, Min-Seon Kim, Han Kyoung Choe, Qingchun Tong, Obin Kwon; Endocrinol Metab. 2021;36(4):745-756. Published online August 27, 2021; DOI: https://doi.org/10.3803/EnM.2021.405

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Intermittent fasting has become an increasingly popular strategy in losing weight and associated reduction in obesity-related medical complications. Overwhelming studies support metabolic improvements from intermittent fasting in blood glucose levels, cardiac and brain function, and other health benefits, in addition to weight loss. However, concerns have also been raised on side effects including muscle loss, ketosis, and electrolyte imbalance. Of particular concern, the effect of intermittent fasting on hormonal circadian rhythms has received little attention. Given the known importance of circadian hormonal changes to normal physiology, potential detrimental effects by dysregulation of hormonal changes deserve careful discussions. In this review, we describe the changes in circadian rhythms of hormones caused by intermittent fasting. We covered major hormones commonly pathophysiologically involved in clinical endocrinology, including insulin, thyroid hormones, and glucocorticoids. Given that intermittent fasting could alter both the level and frequency of hormone secretion, decisions on practicing intermittent fasting should take more considerations on potential detrimental consequences versus beneficial effects pertaining to individual health conditions.

Citations

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Common and divergent molecular mechanisms of fasting and ketogenic diets
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Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models
Hailong Cui, Die Hu, Yanling Liu, Jiejie Zhao
Gene.2024; 896: 148053. CrossRef
Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health
Cristina Manuela Drăgoi, Alina Crenguţa Nicolae, Anca Ungurianu, Denisa Marilena Margină, Daniela Grădinaru, Ion-Bogdan Dumitrescu
Cells.2024; 13(2): 138. CrossRef
Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update
Zahra Sadat Mirrazavi, Vahideh Behrouz
Clinical Nutrition.2024; 43(2): 519. CrossRef
Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim
Diabetes & Metabolism Journal.2024; 48(1): 37. CrossRef
Genetics of Exercise and Diet-Induced Fat Loss Efficiency: A Systematic Review
Aleksandra Bojarczuk, Emiliya S. Egorova, Magdalena Dzitkowska-Zabielska, Ildus I. Ahmetov
Journal of Sports Science and Medicine.2024; : 236. CrossRef
Ramadan fasting in the third trimester of pregnancy and postpartum colostrum cortisol concentrations in Morocco
Meagan M. Guilfoyle
American Journal of Human Biology.2024;[Epub] CrossRef
Dietary factors in circadian rhythm modulation and their impact on metabolic diseases: a state of the science review
Malvika Dalvi, Srujana Medithi
Biological Rhythm Research.2024; : 1. CrossRef
Unlocking the Benefits of Fasting: A Review of its Impact on Various Biological Systems and Human Health
Rawan Mackieh, Nadia Al-Bakkar, Milena Kfoury, Nathalie Okdeh, Hervé Pietra, Rabih Roufayel, Christian Legros, Ziad Fajloun, Jean-Marc Sabatier
Current Medicinal Chemistry.2024; 31(14): 1781. CrossRef
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Sofia K. Forslund
Journal of Internal Medicine.2023; 293(2): 166. CrossRef
Umbrella review of time-restricted eating on weight loss, fasting blood glucose, and lipid profile
Han Shi Jocelyn Chew, Wei How Darryl Ang, Zhen Yang Abel Tan, Wen Wei Ang, Kin Sun Chan, Ying Lau
Nutrition Reviews.2023; 81(9): 1180. CrossRef
Thermodynamic Assessment of the Effects of Intermittent Fasting and Fatty Liver Disease Diets on Longevity
Melek Ece Öngel, Cennet Yildiz, Özge Başer, Bayram Yilmaz, Mustafa Özilgen
Entropy.2023; 25(2): 227. CrossRef
Effects of Intermittent Fasting on Hypothalamus–Pituitary–Thyroid Axis, Palatable Food Intake, and Body Weight in Stressed Rats
Cinthia García-Luna, Ixchel Prieto, Paulina Soberanes-Chávez, Elena Alvarez-Salas, Iván Torre-Villalvazo, Gilberto Matamoros-Trejo, Patricia de Gortari
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Possible homeostatic, glucose uptake mechanisms and hepato-pancreatic histological effects of intermittent fasting, exercise, starvation, and honey in streptozotocin-induced diabetes in rats
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Nutrients.2023; 15(7): 1679. CrossRef
All That Glitters Is Not Gold: The Same Sleep Time, but Different Diabetogenic Outcomes
Bohye Kim, Obin Kwon
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The emerging role of circadian rhythms in the development and function of thermogenic fat
Xuemin Peng, Yong Chen
Frontiers in Endocrinology.2023;[Epub] CrossRef
Time-restricted Feeding Changes as Inspiration for Drug Design
Zhangyuting He, Huayu Yang, Yilei Mao
Current Pharmaceutical Design.2023; 29(8): 559. CrossRef
Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects
Anthony H. Cincotta
International Journal of Molecular Sciences.2023; 24(17): 13255. CrossRef
Adaptive Circadian Rhythms for Autonomous and Biologically Inspired Robot Behavior
Marcos Maroto-Gómez, María Malfaz, Álvaro Castro-González, Sara Carrasco-Martínez, Miguel Ángel Salichs
Biomimetics.2023; 8(5): 413. CrossRef
Intermittent Fasting on Human Health and Disease
Denisa Marilena Margină, Cristina Manuela Drăgoi
Nutrients.2023; 15(21): 4491. CrossRef
Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids
Hasan Al Reza, Zishaan Farooqui, Abid Al Reza, Callen Conroy, Kentaro Iwasawa, Yasuhiro Ogura, Keisuke Okita, Kenji Osafune, Takanori Takebe
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Ruth Sonnweber, Gottfried Hohmann, Jeroen M. G. Stevens, Tobias Deschner, Barbara Fruth, Anna-Lena Fiedler, Niina O. Nurmi, Verena Behringer
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Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease
Patrícia de Castro-de-Paiva, Thatiany de Souza Marinho, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguila
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Optimal Timing of Thyroid Hormone Replacement During Ramadan Fasting: A Randomized Controlled Trial in Patients with Prior Total Thyroidectomy
Khalid M. Al-Qahtani, Ibraheem Ahmed Aldeeri, Amal M. Alshaibi, Norah Salman Alshabib, Rakan M. Barghouthi, Ebtihal Y. Alyusuf, Anwar Ali Jammah
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Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats
Sukanya Bhoumik, Rashmi Kesherwani, Raushan Kumar, Syed Ibrahim Rizvi
Biogerontology.2022; 23(6): 757. CrossRef
Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy
Ming Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang
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Lian Wang, Peijie Chen, Weihua Xiao
Nutrients.2021; 13(10): 3420. CrossRef

Diabetes, Obesity and Metabolism
Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020: Jea Hwa Jang, Obin Kwon, Seok Jun Moon, Yong Taek Jeong; Endocrinol Metab. 2021;36(3):469-477. Published online June 18, 2021; DOI: https://doi.org/10.3803/EnM.2021.302

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Abstract PDF PubReader ePub

Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by sweet and umami tastes, respectively, whereas noxious substances and toxins by bitter or sour tastes. Essential electrolytes including Na⁺ and other ions are recognized by the salty taste. Gustatory information is initially generated by taste buds in the oral cavity, projected into the central nervous system, and finally processed to provide input signals for food recognition, regulation of metabolism and physiology, and higher-order brain functions such as learning and memory, emotion, and reward. Therefore, understanding the peripheral taste system is fundamental for the development of technologies to regulate the endocrine system and improve whole-body metabolism. In this review article, we introduce previous widely-accepted views on the physiology and genetics of peripheral taste cells and primary gustatory neurons, and discuss key findings from the past decade that have raised novel questions or solved previously raised questions.

Citations

Citations to this article as recorded by

Multidimensional exploration of the bitterness amelioration effect of roasting on Wuyi Rock tea
Weiying Su, Li Ni, Yizhe Chen, Daoliang Wang, Chih-Cheng Lin, Yuan Liu, Zhibin Liu
Food Chemistry.2024; 437: 137954. CrossRef
Physiology of the tongue with emphasis on taste transduction
Máire E. Doyle, Hasitha U. Premathilake, Qin Yao, Caio H. Mazucanti, Josephine M. Egan
Physiological Reviews.2023; 103(2): 1193. CrossRef
Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine
Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai
Scientific Reports.2023;[Epub] CrossRef
Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome
Rebeca Fernández-Carrión, Jose V. Sorlí, Oscar Coltell, Eva C. Pascual, Carolina Ortega-Azorín, Rocío Barragán, Ignacio M. Giménez-Alba, Andrea Alvarez-Sala, Montserrat Fitó, Jose M. Ordovas, Dolores Corella
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Case Reports

Secondary Pituitary Hyperplasia Induced by Hashimoto's Thyroiditis Related Hypothyroidism: A Case Report.: Kwang Joon Kim, Hyun min Kim, Obin Kwon, Eun Young Park, Yong ho Lee, Jae Won Hong, Jin Wi, Eun Jig Lee; J Korean Endocr Soc. 2010;25(1):72-77. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.72

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Pituitary hyperplasia associated with untreated primary hypothyroidism in children is a rare condition. There are only a few reports on this condition in children, and especially when pituitary hyperplasia is accompanied with Hashimoto thyroiditis and growth arrest. Here, we describe an unusual association of pituitary hyperplasia with hypothyroidism and growth retardation, and this was all caused by Hashimoto thyroiditis. Hormonal testing showed a low thyroxine level and a high thyroid stimulating hormone level, elevated anti-thyroglobulin, low growth hormone levels and prepubertal levels of gonadotropins. A large intrasellar mass expanding beyond the sella turcica was detected on magnetic resonance imaging (MRI). Homogeneous contrast enhancement of mass highly suggested that it was a pituitary hyperplasia rather than a pituitary tumor. Therapy with L-thyroxine resulted in rapid improvement of the clinical signs, including renewed growth, normalization of the hormone levels and resolution of the pituitary hyperplasia on MRI within 90 days. In children, prolonged unrecognized primary hypothyroidism might be accompanied by growth deficiency and pubertal disharmony. Physicians must be aware of pituitary hyperplasia in these cases.

Citations

Citations to this article as recorded by

Pituitary macroadenoma secondary to Hashimoto’s thyroiditis: inadvertent diagnosis in a pre-pubertal girl
Deepanjan Bhattacharya, Rakesh Kumar, Jaivinder Yadav
Tropical Doctor.2020; 50(3): 240. CrossRef
Pituitary Hyperplasia Secondary to Hypothyroidism Caused by Hashimoto's Thyroiditis in a Female Adolescent
Jeoung Suk Kim, Min Sun Kim, Sun Jun Kim, Gyung Ho Chung, Pyoung Han Hwang, Dae-Yeol Lee
Journal of Korean Society of Pediatric Endocrinology.2011; 16(3): 185. CrossRef

A Case of Insulin Autoimmune Syndrome in a Patient with Partial Hypopituitarism.: Obin Kwon, Eun Young Park, Jin Young Yoon, Kwang Joon Kim, Yong ho Lee, Jae Won Hong, Eun Jig Lee, Sung Kil Lim, Hyun Chul Lee, Bong Soo Cha; J Korean Endocr Soc. 2009;24(4):281-286. Published online December 1, 2009; DOI: https://doi.org/10.3803/jkes.2009.24.4.281

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Abstract PDF: Insulin autoimmune syndrome is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemic hypoglycemia associated with high titer of antibodies to endogenous insulin. We report a case of insulin autoimmune syndrome in a 57-year-old woman, presenting with mental changes due to hypoglycemia. She had no history of diabetes or insulin administration. The serum C-peptide level was 4.69 ng/mL and the insulin concentration was 229.55 microU/mL, when fasting plasma glucose level was 32 mg/dL. The insulin-to-glucose ratio was 7.17, while there was no radiologic evidence of insulinoma. The insulin antibody level was over 100 microU/mL, resulting in the diagnosis of insulin autoimmune syndrome. Hormonal studies revealed partial hypopituitarism and a lack of glucagon-response to hypoglycemia. Hypoglycemia disappeared with replacement of prednisolone with levothyroxine therapy. Under secretion of growth hormone and of adrenocorticotropic hormone due to hypopituitarism were associated with insufficient counterregulation to hypoglycemia. One should keep in mind that insulin autoimmune syndrome or hypopituitarism is one cause of hypoglycemia in patients with no history of diabetes, and corticosteroid can be an effective treatment for both diseases.

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